Case Reports in Ophthalmology
Three-Year Longitudinal Follow-Up of an RPE Tear Using PS-OCT Polarimetric Entropy: A Case Report
By Sakurao Emoto, Yuki Saeki, Kazuki Yashiro and 5 others.
Abstract
Purpose
To report a 3-year ROI-based longitudinal follow-up of an nAMD-associated retinal pigment epithelium (RPE) tear using polarization-sensitive optical coherence tomography (PS-OCT)–derived polarimetric entropy (PE), with concurrent MP-3 microperimetry.
Methods
A 75-year-old woman with an nAMD-related RPE tear was followed for 3 years. At baseline and follow-up visits, decimal best-corrected visual acuity (BCVA), structural OCT findings, en-face PE at the RPE level, and MP-3 retinal sensitivity were recorded. Two fixed regions of interest (ROIs; RPE tear ROI and RPE tear flap ROI) were defined at baseline and propagated across visits using image registration. Mean PE and mean MP-3 sensitivity (dB) were calculated within each ROI.
Results
BCVA improved from 0.3 at baseline to 0.9 at 6 months and 1.0 at 1 year, then declined to 0.7 at 2 years and 0.6 at 3 years, when subretinal fluid (SRF) was present (anti-VEGF administered as needed). From baseline to 6 months, PE increased in both ROIs (RPE tear ROI: 0.085→0.193; RPE tear flap ROI: 0.413→0.543), and MP-3 sensitivity also increased (RPE tear ROI: 10.1→22.0 dB; RPE tear flap ROI: 14.0→19.7 dB). At 1 year, PE was 0.180/0.347 and MP-3 sensitivity was 22.2/17.2 dB in the RPE tear/RPE tear flap ROIs, respectively (BCVA 1.0). At the later SRF-positive visits, PE values were 0.182/0.350 at 2 years and 0.249/0.362 at 3 years, whereas MP-3 sensitivity decreased to 18.8/13.9 dB and 11.9/9.2 dB, respectively.