Cancers
Transcriptomic Convergence Reveals Tumour-Specific Stromal Remodelling in Immune-Enriched Papillary Thyroid Carcinoma
Par Petkova V, Dodova R, Vidinov K et 1 autres.
Contenu en anglais
Résumé
Background
Although immune activation can occur in both papillary thyroid carcinoma (TC) and nodular goitre (NG), the transcriptional programmes distinguishing malignant from non-malignant immune-rich thyroid tissue remain poorly understood.
Methods
In this pilot study, bulk RNA sequencing of 19 specimens (10 TC, 9 NG) allowed classification into four tumour microenvironment (TME) subgroups.