Journal of Korean medical science
Prevalence, Diagnostic Role, and Clinical Features of Zinc Transporter 8 Autoantibody in Korean Children and Adolescents With Diabetes Mellitus
Par Shin S, Woo HA, Lee H et 6 autres.
Contenu en anglais
Résumé
Background
Zinc transporter 8 autoantibodies (ZnT8As) are biomarkers of type 1 diabetes mellitus (T1DM). We evaluated its prevalence, diagnostic utility, and clinical characteristics in Korean children and adolescents with diabetes.
Methods
ZnT8A levels were measured in 288 patients with diabetes mellitus (DM) (aged < 19 years, diagnosed with DM between 2019 and 2025) at two tertiary hospitals and in 100 healthy controls (19-39 years). The ZnT8A positivity cutoff was ≥ 15 U/mL. Clinical features were compared between ZnT8A-positive and ZnT8A-negative patients across diabetes subtypes.