HSAT3 lncRNA regulates replication re-initiation and colocalizes with TOP2A under stress conditions

Background

Long non-coding RNAs transcribed from pericentromeric Satellite 3 repeats (HSAT3) are involved in stress-dependent splicing processes and maintenance of genome stability. The functions of the transcripts are largely unknown, which is mainly due to the predominant heterochromatic organization of satellite regions. HSAT3 expression is induced upon several cellular stressors and builds nuclear stress bodies (nSB), which recruit a large number of RNA-binding and regulatory proteins. Recently, we reported that HSAT3 transcripts induce resistance against the topoisomerase 2a (TOP2A) inhibitor etoposide in lung cancer.