Sphingolipid signatures at the extremes of energy balance: a comparative study of obesity and anorexia nervosa in women

Background

Anorexia nervosa (AN) and obesity (OB) represent opposite extremes of energy balance and are both associated with profound metabolic alterations. Increasing evidence suggests that sphingolipids play a central role in cardiometabolic regulation, inflammation, and insulin signaling; however, clinical sphingolipidomic studies have largely investigated AN and OB separately. Direct comparative studies using a harmonized analytical framework are currently lacking.

Objectives