Frontiers in pediatrics
Incidence and epidemiological characteristics of congenital adrenal hyperplasia in Hangzhou newborns, China (2014-2024): a population-based cross-sectional study
Par Dai Y, Zhu L, Zeng Y et 4 autres.
Contenu en anglais
Résumé
Background
Congenital adrenal hyperplasia (CAH) is a rare but potentially life-threatening autosomal recessive disorder. Its incidence varies by region and ethnicity. This study aimed to evaluate the birth incidence, trends, and clinical characteristics of neonatal classic CAH in Hangzhou (2014-2024) to support regional clinical prevention and management.
Methods
This retrospective population-based study collected data from Hangzhou's information systems. Classic CAH cases were identified through newborn screening and clinical follow-up to age 3, with diagnosis confirmed by pediatric endocrinologists. Incidence was calculated per 100,000 live births. Categorical variables were compared using chi-square or Fisher's exact test. Temporal trend was assessed by Poisson regression.