Open Journal of Physicians and Surgeons
Hyperglycemia-Induced miR-155 Amplifies Inflammatory Cytokine Secretion in Human Mesangial Cells via SOCS1 Suppression
Par Narasimha Sridevi Anand, Kamshid L. Gupta, Shanthi N. Korrapati.
Contenu en anglais
Résumé
Background
Diabetic nephropathy is characterized by chronic low-grade inflammation within renal tissues. MicroRNA-155 (miR-155) is a key regulator of inflammatory cascades; however, its role in mesangial cell injury under hyperglycemic conditions requires clarification.