Multispecimen Genomic Profiling Reveals Inter-Specimen Heterogeneity and Supports Ascites as a Complementary Biospecimen in Pseudomyxoma Peritonei

Background

Pseudomyxoma peritonei (PMP) is a rare peritoneal malignancy with limited genomic data across different biospecimen types. The extent to which ascites and plasma reflect tissue-detected genomic alterations remains incompletely characterized. This study compared genomic profiles across tumor tissue, ascites, and plasma and explored KRAS-defined molecular features in PMP.