Nutrients
Associations Between Gut Microbiota Abundance, Dietary Purine Intake, and Fecal Short-Chain Fatty Acids Across the Clinical Spectrum of Hyperuricemia: A Cross-Sectional Study in Mexican Adults
Door Fuentes-Bello AC, Guevara-Gonzalez KV, Granados-Portillo O en 16 anderen.
Inhoud in het Engels
Abstract
Background
Hyperuricemia and gout are closely associated with alterations in gut microbiota function. Short-chain fatty acids (SCFAs) produced by intestinal microorganisms may modulate immune responses and inflammation relevant to gout pathophysiology. This study evaluated fecal SCFA concentrations, their associations with dietary purine intake, and the relationship between Akkermansia spp. and Prevotella spp. abundance and fecal SCFA profiles across the clinical spectrum of hyperuricemia.