Pharmaceutics
Population Pharmacokinetic Models of Voriconazole in Pediatric Patients: A Systematic Review
Door Wang X, Li M, Yuan X en 1 anderen.
Inhoud in het Engels
Abstract
Background/Objectives: Voriconazole dosing in children is complicated by developmental and nonlinear pharmacokinetics, cytochrome P450 2C19 (CYP2C19) variation, variable oral bioavailability, inflammation, organ dysfunction, and drug interactions. We evaluated the characteristics, reporting completeness, and clinical applicability of pediatric and pediatric-inclusive voriconazole population pharmacokinetic (PopPK) models.