Antibiotics
In Vitro Activity of Aztreonam-Avibactam, Cefiderocol, and Conventional Antimicrobials Against Metallo-β-Lactamase-Producing Gram-Negative Urinary Isolates: A Systematic Review and Local Single-Center Retrospective Evaluation in a Tertiary Care Hospital (2016-2025) and Evaluation of Novel Agents (2021-2025)
Door Requena-Fernández L, Camacho-Blanco N, Rosales-Castillo A en 2 anderen.
Inhoud in het Engels
Abstract
Background
Metallo-β-lactamase (MBL)-producing Gram-negative bacteria represent one of the greatest therapeutic challenges in contemporary clinical microbiology because of their extensive antimicrobial resistance and the limited availability of effective treatment options. Aztreonam-avibactam and cefiderocol have emerged as promising therapeutic alternatives; however, comparative evidence from routine clinical practice remains limited.