CNS neuroscience & therapeutics
Systems Toxicology Indicates AKT1/PTGS2-Centered Neuroinflammatory-Mitochondrial Crosstalk in Lidocaine Associated Neurotoxicity
Door Jiang M, Chen L, Deng J en 5 anderen.
Inhoud in het Engels
Abstract
Background
Lidocaine-containing teething gels are commonly used for pediatric oral analgesia, yet excessive exposure may induce severe neurotoxic effects, including seizure-related events. The molecular mechanisms underlying lidocaine-associated neurotoxicity remain poorly defined.