Joint modeling approaches for predicting conversion from mild cognitive impairment to Alzheimer's disease: A systematic review (1999-2025)

Background

Mild cognitive impairment (MCI) is a critical transition stage toward Alzheimer's disease (AD). While standard longitudinal and survival methods evaluate disease progression separately, joint modeling handles their complex interdependencies. However, no systematic review has exclusively evaluated joint modeling for predicting MCI-to-AD conversion.