Variant-informed multimodal tissue-state modeling reveals an NRF2 stress niche and dependency axis in KEAP1/NFE2L2-altered cancer

Introduction

Cancer genotypes influence transcriptional programs, spatial organization, histopathology, and treatment-response states, yet these molecular and tissue-level features are often analyzed separately in public-data studies. VISTA was developed as a variant-informed, multimodal framework for modeling genotype-linked tissue states and prioritizing validation-ready biological hypotheses.