Distinct Associations of Age and CYP2D6 Genotype With Parent Venlafaxine Exposure and O-Demethylation in Japanese Psychiatric Patients

Background

Venlafaxine (VEN) is converted to O-desmethylvenlafaxine (ODV) mainly through CYP2D6-mediated O-demethylation. However, age-related clinical factors may also influence VEN exposure in routine practice. We examined whether age and CYP2D6 genotype show different associations with parent-drug exposure and metabolic conversion.