Translational vision science & technology
The Effect of Resveratrol, Quercetin, and Curcumin on Drusen Volume in Age-Related Macular Degeneration: A Randomized Clinical Trial
Par Pfahler NM et Knepper PA.
Contenu en anglais
Résumé
Purpose
To evaluate the effect of resveratrol, quercetin, and curcumin (RQC) compared with curcumin alone on drusen volume and clinical outcomes in patients with age-related macular degeneration (AMD).
Methods
In this open-label, randomized phase 2a clinical trial, patients with early and intermediate AMD were randomized 2:1 to oral RQC or curcumin for 24 months. The primary outcome was the mean change in central drusen volume from baseline measured using spectral-domain optical coherence tomography (SD-OCT). Secondary outcomes included analyses of drusen volume and number by baseline size, categorical analyses of individual drusen response, change in best-corrected visual acuity (BCVA), frequency of vision loss, progression to advanced AMD, and safety.