Genes and environment : the official journal of the Japanese Environmental Mutagen Society
Gene-radon interaction effects on lung cancer risk: validation of susceptibility loci using archived DNA from German Uranium miners
Par Rosenberger A, Bonzheim I, Fend F et 7 autres.
Contenu en anglais
Résumé
Background
Radon exposure increases lung cancer risk, shown in studies on indoor exposure (low exposure) and uranium miners (high exposure). Genome-wide and candidate gene studies have identified DNA variants that interact with occupational radon to modify lung cancer risk.