New Vitamin and Mineral Supplements: Acceptability, Tolerability, and Short-Term Adherence in a Paediatric Cohort with IMDs

Background/Objectives: Dietary therapy for inherited metabolic disorders (IMDs) can restrict nutrient-dense foods and increase reliance on vitamin and mineral supplementation. However, formulation-related barriers may limit supplement acceptability and adherence, particularly in children with feeding difficulties and complex dietary regimens. We evaluated the acceptability, gastrointestinal (GI) tolerability, and short-term adherence of two novel low-carbohydrate, low-volume vitamin and mineral formulations in children and adolescents with IMDs.