Oseltamivir-Based Organic Salts and Ionic Liquids: Physicochemical Properties, Cytotoxicity, and Neuraminidase Inhibition

Background

Neuraminidase (NA) inhibitors are widely used for the treatment of influenza, but the emergence of resistance and limitations in drug formulation can compromise their therapeutic performance. This study investigated whether counterion exchange can modulate the physicochemical properties, cytotoxicity, and NA-inhibitory activity of oseltamivir (OS) while preserving its covalent structure.