BH3 Profiling Identifies Apoptotic Priming by SREBP-1/-2 Inhibition and Synergistic Anti-Glioblastoma Activity When Combined with ABT-263 In Vitro

Background/Objectives: Glioblastoma exhibits profound therapy resistance driven in part by complex pro-survival signaling. We hypothesized that targeting lipid metabolism via SREBP-1/2 inhibition (fatostatin) might alter the apoptotic phenotype and facilitate an apoptotic response driven by BH3 mimetics (ABT-263) in glioblastoma in vitro.