Integrated Analysis of Microbiome and Serum Metabolomics to Understand How Rauvolfia vomitoria Alkaloids Inhibit Colorectal Cancer Growth

Background/Objectives: Rauvolfia vomitoria alkaloids (RVA) exhibited excellent activity against colorectal cancer (CRC) growth in the heterotopic model. However, their antitumor effects in the orthotopic models, as well as the underlying mechanisms related to gut microbiota and serum metabolomics, remain poorly understood.

Methods