The Prognostic Value of the Endothelial Activation and Stress Index in Stable Patients with Idiopathic Pulmonary Arterial Hypertension

Background

Endothelial dysfunction and chronic inflammation are central pathophysiological mechanisms in the development of idiopathic pulmonary arterial hypertension (IPAH). EASIX, the endothelial activation and stress index, is a simple and recently introduced score that captures endothelial activation and systemic stress. EASIX has been shown to be associated with several cardiovascular conditions. We investigated the relationship between EASIX and clinical outcomes in stable patients with IPAH.