Journal of clinical medicine
The Impact of Multiple Biologic Failures on Surgical Outcomes: A Retrospective Cohort Study of Elective Subtotal Colectomy for Ulcerative Colitis
Par Rudnicki Y, Jeffery JR, Derakshani D et 1 autres.
Contenu en anglais
Résumé
Background
Subtotal colectomy (STC) with end ileostomy (EI) is usually the first surgical stage for patients with ulcerative colitis (UC) who fail medical treatment, most often with biological agents. Is there a difference in surgical outcome after failure of one or two biologicals vs. three or four?
Methods
A retrospective study of all patients who underwent STC with EI for UC (5-2018 to 1-2022). After excluding emergent cases, the elective cohort was divided into patients who failed 1-2 biologicals (group 1-2) vs. patients who failed 3-4 biologicals (group 3-4), and surgical outcomes were compared. Data collected included patients' demographics, preoperative clinical manifestations, and operative and postoperative outcomes.