Effects of Metformin Treatment on Liver Glucose Metabolism-Related Enzyme Levels in Streptozotocin-Induced Diabetic Rats

Background

Diabetes mellitus (DM) disrupts hepatic glucose handling and alters pathways involved in glycogen metabolism, glycolysis, the pentose phosphate pathway, and gluconeogenesis. This study examined hepatic glycogen content and glucose metabolism-related enzyme levels at defined stages of streptozotocin (STZ)-induced diabetes and evaluated the effect of metformin at week 8.

Methods