Interpretable Modelling of a Streptococcal Exposure-Associated Neuropsychiatric Profile in a Pediatric Cohort

Background/objectives

Pediatric neuropsychiatric presentations in the context of suspected previous streptococcal exposure remain clinically heterogeneous. This study examined whether a predefined clinical-serological profile could be reconstructed within a naturalistic psychiatric cohort using interpretable supervised models and whether discrimination persisted after removing endpoint-proximal predictors.