Phenotypic Landscape of Programmed Death and TIGIT/CD155/DNAM-1 Pathways in NK Cells in Ovarian Cancer

Objectives

Ovarian cancer (OC) is the gynecological malignancy with the highest mortality rate. Preclinical studies have shown that dual blockade of immune checkpoint proteins (ICPs), such as PD-1 and TIGIT, may be beneficial for OC patients. Thus, the aim of this study was to evaluate the expression of PD-1, TIGIT, and DNAM-1 in NK cells in three OC environments-i.e., peripheral blood (PB), peritoneal fluid (PF), and tumor tissue (TT)-and their soluble forms in plasma and PF to explore their clinical significance.