Circulating Soluble Urokinase Plasminogen Activator Receptor and C-Reactive Protein Concentrations in Adults with High-Functioning Autism

Background

Immune dysregulation has been implicated in the pathophysiology of autism spectrum disorder (ASD). Soluble urokinase plasminogen activator receptor (suPAR) is a stable biomarker of chronic immune activation that has not previously been investigated in ASD. We compared circulating suPAR and C-reactive protein (CRP) concentrations in adults with high-functioning ASD and healthy controls.