Multidrug Resistance, Antimicrobial Therapy, and In-Hospital Mortality in Patients with Healthcare-Associated Infections: A Retrospective Cohort Study

Background

Healthcare-associated infections (HAIs), particularly those caused by antimicrobial-resistant pathogens, remain an important cause of adverse outcomes among hospitalized patients. The combined contribution of antimicrobial resistance, clinical characteristics, and antimicrobial treatment to mortality requires further evaluation. This study aimed to investigate factors associated with in-hospital mortality among patients with HAIs, with particular emphasis on multidrug resistance (MDR) and post-culture antimicrobial treatment.