In Vitro Activity of Eravacycline, Aztreonam-Avibactam, and Cefiderocol Against Multidrug-Resistant Gram-Negative Clinical Isolates from a Romanian Tertiary Hospital

Background/objectives

Carbapenem-resistant Gram-negative bacteria-especially NDM- and OXA-48-producing Klebsiella pneumoniae and carbapenem-resistant Acinetobacter baumannii (CRAB)-have limited treatment options, and in vitro data from Eastern Europe on the reserve agents eravacycline, aztreonam-avibactam, and cefiderocol are scarce. We evaluated their in vitro activity against consecutive multidrug-resistant (MDR) Gram-negative isolates from a Romanian tertiary hospital, stratified by species and carbapenemase profile.