MiR-4261 Regulates Granulosa Cell Proliferation Mediated by Progesterone via FZD5 in Human Ovarian Granulosa Cell Line

Background

The effect of different controlled ovarian hyperstimulation (COH) protocols on the microenvironment of follicular growth may be reflected by microRNA (miRNA) expression profiles. Downregulation of miR-4261 when progesterone is added in the follicular phase has been reported in our previous research. The purpose of this study is to observe how miR-4261 regulates the function of granulosa cells, so as to find the specific pathway and mechanism of progesterone acting on the follicular microenvironment.