Anticipating the Next Recorded Bacterial Hosts of Plasmid-Borne Antimicrobial Resistance Genes: A Temporal Graph Analysis of Plasmid and Surveillance Data

Background/objectives

Plasmid-mediated dissemination of antimicrobial resistance genes complicates the control of bacterial infections. Identifying bacterial hosts likely to harbour these genes could guide genomic surveillance before such associations enter public databases. We investigated whether existing plasmid and surveillance data could anticipate which resistance gene-host associations would next be recorded in those databases, and which genomic features inform that prediction.