Clinical Characteristics of End-Organ Failure as a Cause of Primary Amenorrhea: Multicenter Study in Korean Population

Background

Primary amenorrhea is defined as the absence of menstruation by the age of 13 years in the absence of secondary sexual characteristics or by age 15 in the presence of normal secondary sexual development. It has multiple potential causes, and accurate diagnosis is crucial for effective treatment. This study aimed to provide insights into the incidence and distribution of primary amenorrhea due to congenital anomalies or disorders of sexual development (DSD) in Korea.