Alzheimer's & dementia : the journal of the Alzheimer's Association
Pathway-specific polygenic risk scores modify the association between amyloid and tau PET accumulation in patients with Alzheimer's disease
Par Valentim C, Denecke J, Frerich S et 7 autres.
Contenu en anglais
Résumé
Background
Genome-wide association studies (GWASs) identified multiple genetic variants associated with Alzheimer's disease (AD) risk, yet the biological pathways linking these to amyloid and tau pathology remain unclear.