Integrative Analysis of m6A Methylation and Transcriptomic Profiles in Cortical Tissues of Mice with Sepsis-Associated Encephalopathy

Background

Sepsis-associated encephalopathy (SAE) is a common and severe complication in septic patients, characterized by the increased mortality and cognition dysfunction. N6-Methyladenosine (m6A), one of the most prevalent RNA modifications, plays crucial roles in the central nervous system by regulating RNA metabolism. However, its involvement in the pathogenesis of SAE remains unexplored.