Synthesis, Characterization, and Multifunctional Applications of Chitosan-Grafted-Poly(Acrylic Acid-Co-Acrylamide)/ZnO Nanocomposite Hydrogel: Loading Studies, Antimicrobial Activity, Wound Healing, and Anticancer Potential

Background

Effective wound dressings must combine antimicrobial action with support of tissue repair. Chitosan hydrogels are biocompatible but weakly antimicrobial, whereas ZnO nanoparticles are potent antimicrobials that need a carrier matrix. Most studies address either loading chemistry or biological performance, rarely both. Here, the ZnO-loading chemistry of a CH-g-P(AA-co-Am)/ZnO nanocomposite hydrogel is linked to its biological behaviour.