Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
Expression of TTP in esophageal adenocarcinoma and its inhibition on epithelial-mesenchymal transition in esophageal adenocarcinoma cells
Par Fang Z, Chen X et Luo Q.
Contenu en anglais
Résumé
Objectives
Tristetraprolin (TTP), an important RNA-binding protein, regulates cell proliferation and differentiation by degrading target mRNAs; however, its role in the development and progression of esophageal adenocarcinoma (EAC) remains unclear. This study aims to detect the expression of TTP in EAC tissues and its relationship with clinicopathological features, and to investigate the effects of TTP overexpression on the proliferation of EAC cells and its underlying molecular mechanisms, thereby providing a basis for elucidating the role of TTP in the development and progression of EAC.