BMJ open respiratory research
Hypoxic burden, systemic inflammation and respiratory muscle dysfunction in obstructive sleep apnoea: a multicentre cross-sectional study
Par Tariq A, Saad A et Zadeh SAM.
Contenu en anglais
Résumé
Background
Obstructive sleep apnoea (OSA) is characterised by intermittent hypoxaemia and systemic inflammation. Hypoxic burden has emerged as a physiologically relevant marker of disease severity, but its relationship with inflammatory biomarkers and respiratory muscle strength remains unclear.
Methods
In this multicentre cross-sectional study, 137 adults with suspected OSA from tertiary care centres in Lahore, Pakistan underwent overnight attended polysomnography using standardised protocols. Hypoxic burden was quantified as the cumulative area under the oxygen desaturation curve across sleep. Fasting blood samples were analysed for C reactive protein (CRP), interleukin-6, tumour necrosis factor-alpha, neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio using standard laboratory methods. Respiratory muscle strength was assessed using maximal inspiratory and expiratory pressures. Clinical, anthropometric and questionnaire-based data were also collected. Multivariable linear regression models were used to examine factors independently associated with hypoxic burden and systemic inflammation after adjustment for potential confounders.