The Resistance Constellation Across the Sepsis-Uropathogen Continuum: A Thirteen-Year Atlas of Epidemiological Expansion, Resistance Kinetics, and Progressive Therapeutic Attrition

Background

Conventional antibiograms compress antimicrobial resistance (AMR) into static percentages, obscuring whether therapeutic space is being lost gradually in high-burden pathogens or rapidly in less prevalent but increasingly resistant organisms. We developed a multidimensional longitudinal framework to map the evolving "resistance architecture" of bloodstream and urinary pathogens by integrating pathogen burden, demographic redistribution, specimen compartment, resistance velocity, and remaining antimicrobial-class activity.