Bilayer Polycaprolactone (Mitomycin C)/Poly(L-Lactic Acid)/Gelatine (Dimethyloxalylglycine) Nanofibres for Diabetic Wound Repair

Background

Diabetic skin wounds arise from chronic hyperglycaemia, peripheral neuropathy, microvascular dysfunction, and compromised immunity. Chronic ulcers are further complicated by infection and local ischaemia-hypoxia, which collectively impede tissue repair. Conventional interventions, including glycaemic control, anti-infective therapy, debridement, and wound dressings, can only partially relieve clinical symptoms. Since these strategies fail to reverse ischaemia-hypoxia or restore the reparative capacity of endogenous cells, ulcers often recur, healing outcomes remain unsatisfactory, and limb amputation may become unavoidable. To overcome these drawbacks, we fabricated a bilayer electrospun microfibre membrane for diabetic wound repair.