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Medical sciences
Par Guamán Espinoza SB, Cantos-Macías SM, Reyes LFC et 4 autres.
Contenu en anglais
This study assessed the association between serum ascorbic acid and zinc levels and depressive symptoms in young Ecuadorian adults.
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A case-control study was conducted among individuals aged 18-34 years. A total of 88 young adults were included based on PHQ-9 scores: 44 with moderately severe-to-severe depressive symptoms (PHQ-9 ≥ 15) and 44 with lower depressive symptom severity (PHQ-9 < 15). Serum samples were collected to measure ascorbic acid and zinc concentrations. We also collected sociodemographic data, sleep patterns, and self-reported frequency of consumption of vitamin C- and zinc-rich foods.
Low serum ascorbic acid (<0.30 mg/dL) was observed in 75% of individuals with PHQ-9 ≥ 15 and 43.2% of those with PHQ-9 < 15 (p = 0.002). Multivariable analysis showed that each 0.1 mg/dL decrease in serum ascorbic acid (aOR = 1.78; 95% CI: 1.25-2.66; p < 0.001) were associated with higher odds of moderately severe-to-severe depressive symptoms. In crude analyses, sleeping less than 6 h (OR = 3.75; 95% CI: 1.47-10.03; p = 0.005) and going to bed after midnight (OR = 3.59; 95% CI: 1.48-9.16; p = 0.004) were associated with higher odds of moderately severe-to-severe depressive symptoms. Lower self-reported frequency of consumption of vitamin C-rich foods was also associated with higher depressive symptom severity. Zinc levels showed no significant association.
Our results show that lower serum ascorbic acid levels are significantly associated with depressive symptoms in young adults. Healthy sleep patterns and more frequent consumption of vitamin C-rich foods were more common in young adults with lower depressive symptom severity.
Publié dans Medical sciences (Basel, Switzerland). Le résumé est reproduit tel qu’il a été publié et reste l’œuvre de ses auteurs ; lisez l’article complet à la source.
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