Positive Allosteric Modulation of mGlu and Muscarinic Receptors Differentially Regulate Nitric Oxide-Dependent Signaling in a Scopolamine-Induced Model of Cognitive Impairment

Background/Objectives: The aim of the study was to evaluate the effects of positive allosteric modulators (PAMs) of metabotropic glutamate (mGlu2, mGlu5) and muscarinic (M1, M4) receptors on nitric oxide (NO֗)-dependent pathways. Scopolamine-induced cognitive impairment model reflecting cholinergic dysfunction characteristic of Alzheimer's disease was used.