Systems Toxicology Indicates AKT1/PTGS2-Centered Neuroinflammatory-Mitochondrial Crosstalk in Lidocaine Associated Neurotoxicity

Background

Lidocaine-containing teething gels are commonly used for pediatric oral analgesia, yet excessive exposure may induce severe neurotoxic effects, including seizure-related events. The molecular mechanisms underlying lidocaine-associated neurotoxicity remain poorly defined.