Turkish journal of ophthalmology
Comparison of Optical Coherence Tomography Biomarkers in Nonproliferative and Proliferative Diabetic Retinopathy: Marmasia Study Group Report No. 2
Par Özsoy Saygın I, Kumral Türkseven E, Kaplan FB et 19 autres.
Contenu en anglais
Résumé
Objectives
To compare structural optical coherence tomography (OCT) biomarkers and visual acuity between eyes with nonproliferative (NPDR) and proliferative diabetic retinopathy (PDR) in real-life clinical settings.
Materials and methods
This retrospective, cross-sectional, multicentre study included 818 eyes of 534 patients with treatment-naive diabetic macular oedema (DMO) from nine tertiary clinics. Evaluated parameters included central macular thickness (CMT), DMO morphology, disorganisation of the retinal inner layers, ellipsoid zone (EZ) integrity, vitreoretinal interface abnormality (VRIA), and posterior hyaloid status. Analyses used eye-level data with patient-clustered robust standard errors and study-centre fixed effects. A joint multivariable logistic model mutually adjusted EZ integrity, posterior hyaloid status and VRIA together with clinical covariates, with Holm correction across six structural-domain tests.