α-synuclein pathology drives region-specific tau deposition

Introduction

Dementia with Lewy bodies (DLB) is a common but underdiagnosed neurodegenerative disease associated with α-synuclein pathology. Clinically, DLB is characterized by early motor dysfunction and psychiatric symptoms, in contrast to early memory decline typical of Alzheimer's disease (AD). Lewy body and AD pathology commonly co-occur. It remains unclear how α-synuclein pathology, either alone or in combination with AD pathology, produces clinical features considered distinctive of synucleinopathy.