Prevalence and impact of Thiopurine S-methyltransferase (TPMT) and Nudix hydrolase 15 (NUDT15) polymorphisms on the occurrence of myelosuppression in Thai patients with inflammatory bowel disease receiving thiopurine therapy

Introduction

Thiopurine-induced myelosuppression (TIM) is an important side effect influenced by 2 main genetic polymorphisms, thiopurine-S-methyltransferase (TPMT) and NUDT15. The data on Southeast Asian inflammatory bowel disease (IBD) patients remain limited. Our study aimed to determine the relationship between TPMT and NUDT15 polymorphisms and TIM following thiopurine treatment in Thai patients with IBD.