Pneumonia
Respiratory pathogens across rural populations: general practice patients with community-acquired pneumonia, residents, and goat farmers
Par Roof I, Lotterman A, de Rooij MMT et 5 autres.
Contenu en anglais
Résumé
Background
Residents living near goat farms (< 2000 m) in the Netherlands have consistently shown an elevated risk of pneumonia, yet the pathogens underlying this association remain unknown. This study assessed the presence of 33 respiratory pathogens, including bacteria, viruses, and fungi, across rural populations with different goat farm exposures.
Methods
This cross-sectional study included general practitioner (GP)-diagnosed pneumonia patients (PP; n = 108), non-farming rural residents without pneumonia (NFR; n = 200), and goat farm workers (GFW; n = 91). Oropharyngeal and nasopharyngeal swabs were collected and analyzed by a multiplex and two additional PCR test targeting in total 12 bacteria, 20 viruses and 1 fungus. Between-group differences in detection were assessed by Fisher's exact tests. Logistic regression analyses were performed to assess associations between pathogen detection and residential proximity to goat farming and other covariates.