European journal of clinical investigation
Fertility Treatment and Risk of Melanoma: A Certainty-Rated Systematic Review and Meta-Analysis of 3,733,499 Women
Par Stylianakis D, Solinas C, Petrelli F et 9 autres.
Contenu en anglais
Résumé
Background
Cancer safety after fertility treatment is well studied for breast and gynaecological tumours, but melanoma risk remains poorly characterized. We synthesized internally controlled evidence on this association.
Methods
PubMed/MEDLINE, Scopus, Cochrane Library, and ClinicalTrials.gov (2000-2025) were searched for comparative observational studies of melanoma incidence. The primary outcome was incident melanoma; treatment-pathway/SIR analyses were secondary. Hazard ratios and case-cohort relative risks (rare-disease approximation) were pooled using random-effects meta-analysis (REML, Hartung-Knapp) in R; SIRs were synthesized separately. Risk of bias was assessed with ROBINS-E and certainty graded using GRADE.