Anemia, hematinic deficiencies, and hyperhomocysteinemia in gastric parietal cell antibody-positive and -negative recurrent aphthous stomatitis patients

Background/purpose

Our previous study found the serum gastric parietal cell antibody (GPCA) positivity in 12.8% of 430 recurrent aphthous stomatitis (RAS) patients. This study assessed whether GPCA-positive RAS (GPCA+RAS) patients had significantly higher frequencies of macrocytosis, anemia, hematinic deficiencies, and hyperhomocysteinemia than healthy control subjects or GPCA-negative RAS (GPCA-RAS) patients.