Anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody positivity in recurrent aphthous stomatitis patients with vitamin B12 deficiency

Background/purpose

Our previous study found that 30 of 430 recurrent aphthous stomatitis (RAS) patients have vitamin B12 deficiency. This study assessed whether the vitamin B12-deficient RAS (B12D/RAS) patients had significantly higher frequencies of anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody (GPCA) positivity than healthy control subjects and evaluated whether all B12D/RAS patients had pernicious anemia (PA).