Potential anti-osteoporotic and anti-inflammatory potential of plant derived extracts and column semi-purified fractions of Epimedium brevicornum

Background

Osteoporosis is characterized by excessive bone resorption and impaired bone remodeling, often accompanied by inflammatory processes that exacerbate skeletal deterioration. Natural products with multi-target potential have gained attention as alternative therapeutic strategies. The present study aimed to investigate the in-vitro anti-osteoporotic and anti-inflammatory potential of extracts obtained from different parts of Epimedium brevicornum, including leaves, stem, and roots, as well as isolated column semi-purified fractions (E-B-1 C, E-B-2 C, E-B-3 C, and E-B-4 C) derived from the leaf extract.